… of numerous protein kinases is allosterically modulated by … αC helices), the αC helix plays
a key role in switching protein … In all examples, the displacement of the αC helix stabilizes …

… and αC helix in/out in the active/inactive protein kinase. Different orientations of DFG motif
and αC helix in … Besides, the displaced αC helix and Arg 255 together trap the most N-terminal …

… Due to their critical role in cellular signaling, protein kinases … allosteric back pocket ligands
require a displaced αC-helix … the discovery of allosteric modulators for two kinases, and the dif…

… and discovery of kinase inhibitors and allosteric modulators of kinase activation. The lessons
… -in/αChelix-out kinase conformation, in which the αC-helix is displaced outwards from the …

… helix incorporates portions of both CBDs, including the αB and αC helices from CBD-A and
the αN helix … indication of this flexibility, because the displacement of CBD-B relative to CBD-A…

… protein-coupled receptors, nuclear hormone receptors and receptor tyrosine kinases are all
allosteric proteins … orientation of the “activation loop” and αC helix in the N-lobe of the TK to …

… allosteric regulatory machinery of protein kinases and provide … , ordering or displacement of
the αC-helix, and modulation of … Although binding of allosteric modulators of protein kinases …

… by the α-C-helix displacement and the DFG motif characterized … Other more general
approaches to identify allosteric pockets … an alias for protein kinase AMP-activated catalytic …

… the Mitogen-Activated Protein Kinase (MAPK) signalling … decreased folding (3 10 -helix ↔
turn) and displaced β-hairpin. The … allosteric modulators bound to its area close to the αC-helix …

… of protein kinases, which often involve the allosteric modulation … mediated by the helix αC
in many other protein kinases. … displaced the interaction of PDK1 with PIFtide allosterically but …